Harnessing new molecular technology to investigate E coli O157

Organisation : NHS Lothian
Grant Amount : £ 88,926

E. coli O157 causes bloody diarrhoea, haemolysis and kidney failure, and Scotland consistly has the highest incidence rate in the UK, 200-250 cases occurring per annual (40% hospitalised: 1% fatal). Whole-genome sequencing (WGS) reveals the genetic make-up and evolution of micro-organisms giving information on their relatedness and ability to cause disease. The aim of this project is to use novel WGS technology to study E. coli O157 strains isolated from Lothian patients over the last 5 years to provide information to support optimum clinical and Public Health Interventions to reduce morbidity and mortality.