Does metformin treat diabetes by inhibiting cortisol regeneration 11b-HSD1 ?

Organisation : University of Edinburgh
Grant Amount : £ 19,989

11?-HSD1 inhitors are a new class of anti-diabetic drugs, invented in Edinburgh, designed to lower steroid (cortisol) levels in tissues and hence glucose levels in blood. However, 11?-HSD1 inhibitors only have modest effects in diabetics receiving metformin, perhaps because (as we have shown in health people) metformin decreases 11?-HSD1 activity in patients with diabetes, which may contribute to the beneficial effects of metformin and may also explain the disappointing effects of 11?-HSD1 inhibitors in patients receiving both drugs, allowing better selection of patients who will respond in ongoing clinical trials