Research has revealed differences in the treatment and outcome of men and women suffering heart attacks. The influence that gender may have on patient presentation, and the doctors’ perception of patient risk may explain these findings. Differences in perception of patient risk will be investigated in patients attending A+E with chest pain, by asking the doctor to rate their perception of whether symptoms are due to a heart attack before test results are available. The final diagnosis and treatment plan for each patient will be recorded. In a separate case study evaluation, doctors’ perceptions of patient symptoms will be compared between men and women to understand how gender might affect diagnosis and management.The results of this study will help provide important information for clinical guidance and clinical training in the assessment of chest pain in men and women.